Vaccines save millions of lives every year. They work by training the body’s immune system to recognize and ward off viruses and bacteria. With the COVID-19 vaccine spreading around the globe, people have expressed mixed emotions about the vaccine. While most were elated with the news and had high hopes for it, others were a little skeptical. The average person does not understand how the vaccine will work on our bodies or how our bodies will react to it. However, a lot of information is now available about how and when research began, the technology used, how it works in our body and the side effects.  


Synthetic messenger RNA (mRNA), is an ingenious variation on the natural substance that provides instructions or serves as a blueprint for protein production in cells throughout the body. By making precise modifications to synthetic mRNA and injecting people with this blueprint, any cell in the body could be transformed into an on-demand drug factory. Before this was a multibillion-dollar idea, it was a scientific backwater. Katalin Kariko, a Hungarian biochemist, specializes in RNA-mediated mechanisms. She dedicated her work attempting to harness the power of mRNA to fight disease. However, she was faced with rejections and didn’t receive any support in the form of government grants, corporate funding or even support from her colleagues. After partnering with Drew Weissman and tweaking her current work, they discovered a solution to the existing mRNA research. Today, Moderna and Pfizer, have used this mRNA research that started three decades ago in an attempt to end this global pandemic and save lives. 


Most vaccines introduce weakened or inactive versions of the virus in the body for it to make antibodies. The COVID-19 vaccine has strands of genetic material called mRNA inside a special coating. That coating protects the mRNA from enzymes in the body that would otherwise break it down once it entered the body. mRNA can most easily be described as instructions for the cell on how to make a piece of the “spike protein” that is unique to SARS-CoV-2. Since only part of the protein is made, it does not do any harm to the person vaccinated. After the piece of the spike protein is made, the cell breaks down the mRNA strands and disposes of them using enzymes in the cell. Once displayed on the cell surface, the protein causes the immune system to begin producing antibodies and activating T-cells to fight off what it thinks is an infection. These antibodies are specific to the SARS-CoV-2 virus, which means the immune system is primed to protect you against future infection.


Patients considering vaccination may worry about the short-term and long-term side effects of taking the vaccine. The most common side effect of the vaccine is pain/soreness at the injection site. Other commonly reported side effects include fever, fatigue, muscle aches or headache, but these are usually mild and resolve in a few days. Serious reactions are uncommon and include rare cases of severe allergic reactions. Caution is advised for anyone who has a history of serious allergic reactions to vaccines or injections in the past. The mRNA does not enter the cell nucleus so it cannot alter or affect your DNA. it has also not been linked to infertility or miscarriage as suggested by many rumours.


The delivery of the COVID-19 vaccine will be prioritized since it is limited in terms of quantity at the moment. The CDC has recommended phases in which different groups of people should receive the vaccine, but currently it is up to individual States to set exact criteria for who is included in these phases. For the State of Georgia, this link provides updates on current phases.  As the vaccine becomes more readily available, additional groups will be vaccinated. 

Buckhead Medicine is a premier concierge medicine practice in Atlanta. We provide quality, attentive and personalized medical care to people with physician access 24/7. We have also been approved for international testing and offer COVID-19 tests like the COVID-19 RT-PCR Test, COVID-19 Rapid Molecular Test, COVID-19 Rapid Antigen Test and the COVID-19 IgG Serum Antibody Test. check out our website for information. Visit our page to find out about COVID-19 testing in Atlanta. Read our blogs for more information about the COVID-19 vaccination and how long you have to isolate for if you were exposed to COVID-19